Utjecaj mikrobiote na ekspresiju gena i funkciju epitela crijevne sluznice

master's thesis

• Title (english): Impact of the microbiote on gene expression and function of intestinal mucosa
• Author: Monika Šurić
• Mentor: Krešimir Salajpal (mentor)
• Committee member: Krešimir Salajpal (predsjednik povjerenstva)
• Committee member: Danijel Karolyi (član povjerenstva)
• Committee member: Kristina Kljak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Agriculture; (Animal Science); Zagreb
• Defense date and country: 2019-09-26, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Agronomy

Abstract

Skupina mikroorganizama koja obitava u crijevima naziva se mikrobiota, a njihova ravnoteža utječe na funkciju probavnog sustava, zdravlje domaćina te djelomično kontrolira ekspresiju tkivno specifičnih gena domaćina. Geni crijevne sluznice uključuju gene povezane s crijevnim urođenim imunološkim odgovorom, poput interleukina i peptida obrane domaćina (HDP), te gene koji su uključeni u funkciju crijevne barijere i osjetljivost na hranjive tvari, uključujući mukozu (MUC), proteine uskih spojeva, receptore slobodnih masnih kiselina (FFAR) i transportere glukoze (GLUT). Funkcije stanica sluznice crijeva i ekspresija navedenih gena je, zbog neposredne izloženosti, pod utjecajem mikrobiote crijeva. Mnogi proizvodi, uključujući antibiotike, organske kiseline, probiotike, prebiotike i biljni ekstrakti, se primjenjuju s ciljem promjene mikrobiote u korist razvoja zdravog gastrointestinalnog sustava koji kao posljedicu ima sposobnost zaštitite domaćina od bolesti te poboljšanje njegovih proizvodnih karakteristika.

Abstract (english)

A group of microorganisms inhabited in the gut is called microbiota, and their balance affects the function of the digestive system, the health of the host and partially controls the tissue-specific transcription of the host gene. Genes of the intestinal mucosa include genes associated with the intestinal innate immune responses, such as interleukin and host defense peptides (HDP), genes involved in the intestinal barrier function and nutrient sensitivity, including mucosa (MUC), tight junction proteins, free fatty acid receptors (FFAR) and glucose transporters (GLUT). The function of the gut mucosal cells and the expression of these genes is, due to direct exposure, influenced by the gut microbiota. Many products, including antibiotics, organic acids, probiotics, prebiotics, and herbs, are used to change the microbiota in favor of developing a healthy gastrointestinal system that, as a consequence, has the ability to protect the host from diseases and improve its production characteristics.

• Keywords: mikrobiota; gastrointestinalni sustav; HDP; geni barijerne funkcije crijeva; geni nutritivne osjetljivosti
• Keywords (english): microbiota; gastrointestinal tract; HDP; intestinal barrier function genes; nutrient sensing genes
• Language: croatian
• URN:NBN: urn:nbn:hr:204:498821
• Study programme: Title: Animal Genetics and Breeding; Study programme type: university; Study level: graduate; Academic / professional title: magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja (magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2019-10-23 12:32:23