Mehanizam djelovanja steroidnih hormona i regulacija ekspresije gena

master's thesis

• Title (english): Mechanism of steroid hormone action and gene expression regulation
• Author: Iris Jurki
• Mentor: Krešimir Salajpal (mentor)
• Committee member: Krešimir Salajpal (predsjednik povjerenstva)
• Committee member: Bruna Tariba (član povjerenstva)
• Committee member: Dragica Šalamon (član povjerenstva)
• Granter: University of Zagreb; Faculty of Agriculture; (Department of Animal Science I); Zagreb
• Defense date and country: 2021-09-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Agronomy

Abstract

Proces uključivanja gena u cilju produkcije RNK i proteina naziva se genska ekspresija, dok se proces regulacije koji će se geni u stanici DNK koristiti da se napravi funkcionalni produkti naziva nadzor nad genskom ekspresijom. Steroidni hormoni su bilo koja grupa hormona koji pripadaju skupini kemijskih spojeva steroida. Njihov mehanizam rada temelji se na interakciji sa tkivno specifičnim vezivnim mjestima i nastanku hormon-receptor kompleksa. Iako se steroidi mogu podijeliti u nekoliko grupa, generalni mehanizam djelovanja im je zajednički. Oni potiču sintezu specifičnih proteina u staničnim reakcijama što utječe na razne tipove stanica i to daje vrlo različite odgovore od kojih je svaki karakterističan za određeni steroid i njegovo ciljno tkivo. Detaljnije istraživanje steroidnih hormona i ekspresije gena omogućiti će manipuliranje rezultatima njihovog utjecaja.

Abstract (english)

The process of gene incorporation to produce RNA and proteins is called gene expression, while the process of regulating which genes in a DNA cell will be used to make functional products is called gene expression control. Steroid hormones are any group of hormones that belong to the class of chemical compounds od steroids. Their mechanism of action is based on the interaction with tissue specific binding sites and the formation of hormone-receptor complexes. Although steroids can be divided into several groups, the general mechanism of action is the same. They stimulate the synthesis of specific proteins in cellular reactions which affects different cell types and gives various responses, each characteristic for a particular steroid and its target tissue. A more detailed study of steroid hormones and gene expression will make it possible to manipulate the results of their influence.

• Keywords: ekspresija gena; steroidni hormoni; steroidni receptori; transkripcija
• Keywords (english): gene expression; steroid hormones; steroid receptors; transcription
• Language: croatian
• URN:NBN: urn:nbn:hr:204:259363
• Study programme: Title: Animal Genetics and Breeding; Study programme type: university; Study level: graduate; Academic / professional title: magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja (magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-12-10 08:24:41