Identifikacija signala pozitivne selekcije u genomu pastirskih pasa

master's thesis

• Title (english): Identifying signatures of positive selection in shepherd dogs´ genome
• Author: Vjeran Glavaš
• Mentor: Vlatka Čubrić Čurik (mentor)
• Committee member: Vlatka Čubrić Čurik (predsjednik povjerenstva)
• Committee member: Ino Čurik (član povjerenstva)
• Committee member: Maja Ferenčaković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Agriculture; (Animal Science); Zagreb
• Defense date and country: 2021-09-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Agronomy

Abstract

Umjetna selekcija koja se provodi na psima (Canis lupus familiaris) predstavlja jedan od najzanimljivijih primjera selekcije, kako zbog velikog broja jedinki tako i zbog širok spektra varijacija unutar specifičnih morfoloških i bihevioralnih karakteristika pojedine pasmine. U ovom istraživanju korišteni su genomski podaci 123 jedinke pastirskih pasmina pasa s ukupno 107.403 SNP-ova na kojima su provedene iHS i eROHi analize u svrhu otkrivanja signala pozitivne selekcije. Metode su se temeljile na otkrivanju genomskih varijacija unutar jedne velike meta-populacije od 11 različitih pastirskih pasmina pasa. Provedeno istraživanje obuhvatilo je i identifikaciju gena kao i proučavanje njihove funkcionalnosti unutar psećeg organizma. Uspješno je identificirano 29 regija pod selekcijom s pripadajućih 462 gena koji utječu na ekspresiju važnih morfoloških i bihevioralnih karakteristika.

Abstract (english)

Artificial selection in dogs (Canis lupus familiaris) is one of the most interesting examples of selection, both because of the large number of individuals and the wide range of variation within the specific morphological and behavioral characteristics of each breed. In this study, genomic data from 123 individuals of shepherd dog breeds with a total of 107,403 SNPs was used, on which iHS and eROHi analyzes were performed to detect positive selection signals. The methods were based on the detection of genomic variation within a large meta-population of 11 different shepherd dog breeds. The studies performed included both the identification of genes and the study of their functionality within the canine organism. Twenty-nine regions that are under positive selection were identified as well as 462 genes that play a crucial role in development of certain morphological and behavioral characteristics.

• Keywords: selekcija; iHS; eROHi; varijacije; geni
• Keywords (english): Selection; iHS; eROHi; Variations; Genes
• Language: croatian
• URN:NBN: urn:nbn:hr:204:518213
• Study programme: Title: Animal Genetics and Breeding; Study programme type: university; Study level: graduate; Academic / professional title: magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja (magistar/ magistra inženjer/inženjerka genetike i oplemenjivanja životinja)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-12-02 12:12:15