Primjena bakteriocina bakterija mliječne kiseline u liječenju humanih urinarnih infekcija

master's thesis

• Title (english): Application of lactic acid bacteria bacteriocins in the urinary tract infections treatment
• Author: Marin Mrša
• Mentor: Dubravka Samaržija (mentor)
• Committee member: Dubravka Samaržija (predsjednik povjerenstva)
• Committee member: Iva Dolenčić Špehar (član povjerenstva)
• Committee member: Milna Tudor Kalit (član povjerenstva)
• Granter: University of Zagreb; Faculty of Agriculture; (Department of Dairy Science); Zagreb
• Defense date and country: 2021-01-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOTECHNICAL SCIENCES; Agronomy

Abstract

Unutar infektivnih humanih bolesti, urinarna infekcija danas je postala globalni problem. Sama pojava urinarnih infekcija češća je kod žena i kod osoba s povećanim rizikom od neuspješnog liječenje (dijabetes, trudnoća, itd.), a učestalost nastanka urinarnih infekcija povezana je s godinama. Najčešći uzročnici urinarnih infekcija su uropatogena Escherichia coli (UPEC), Klebsiella pneumoniae, Staphylococcus saprophyticus, Enterococcus faecalis, Enterococcus spp., Staphylococcus aureus i Candida spp. Bakteriocini bakterija mliječne kiseline (BMK) su heterogena skupina bioaktivnih antimikrobnih proteina koji imaju inhibitorno djelovanje prema mnogim mikrobnim vrstama i ne stvaraju rezistentnost. Stoga je u području medicine proizašao veliki interes za bakteriocinima koji već imaju široku primjenu u prehrambenoj industriji kao konzervansi. Interes za bakteriocine BMK u području medicine proizašao je iz alarmantnog porasta rezistentnosti patogenih bakterija na večinu danas poznatih antibiotika te njihovih štetnih učinaka na ljudski organizam. Porast otpornosti bakterija na antibiotike umanjuje učinkovitost same terapije pri liječenje urinarnih infekcija stoga je potrebno pronaći alternativnu zamjenu antibioticima. Usprkos širokoj primjeni bakteriocina BMK u prehrambenoj industriji, radi rigoroznih zakonskih propisa njihova je primjena u medicini uglavnom ograničena.

Abstract (english)

Within infectious human diseases, urinary tract infections have become a global problem nowadays. Occurrence of urinary tract infections itself is more common in women and persons with higher risk of treatment failure (diabetes, pregnancy, etc.). Frequency of urinary tract infections is related to age. Most common pathogens of urinary tract are uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae, Staphylococcus saprophyticus, Enterococcus faecalis, Enterococcus spp., Staphylococcus aureus i Candida spp. Lactic acid bacteria (LAB) bacteriocins are heterogeneous group of bioactive antimicrobial proteins that have inhibitory activity against many microbial species and do not cause resistance. Therefore, in the field of medicine there has been great interest in bacteriocins which are already widely used in the food industry as preservatives. The interest in LAB bacteriocins in the field of medicine stemmed from the alarming increase in the resistance of pathogenic bacteria to most of the antibiotics known today and their harmful effects on the human body. The increase in bacterial resistance to antibiotics reduces the effectiveness of the therapy itself in the treatment of urinary tract infections, therefore it is necessary to find an alternative to antibiotics. Despite the widespread use of LAB bacteriocins in the food industry, due to rigorous legislation, their use in medicine is generally limited.

• Keywords: urinarne infekcije; uropatogeni; antibiotici; bakterije mliječne kiseline; bakteriocini
• Keywords (english): urinary infections; uropathogens; antibiotics; lactic acid bacteria; bacteriocins
• Language: croatian
• URN:NBN: urn:nbn:hr:204:846266
• Study programme: Title: Production and Processing of Milk; Study programme type: university; Study level: graduate; Academic / professional title: magistar / magistra inženjer/inženjerka proizvodnje i prerade mlijeka (magistar / magistra inženjer/inženjerka proizvodnje i prerade mlijeka)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-01-28 12:43:46